PERSISTENT PAIN MODEL REVEALS SEX DIFFERENCE IN MORPHINE POTENCY Running Head: Sex differences in morphine analgesia
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CALL FOR PAPERS Sex and Gender Differences in Pain and Inflammation Persistent pain model reveals sex difference in morphine potency
peripherally mediated Sex differences in morphine-induced analgesia of visceral pain are supraspinally and including high-resolution figures, can be found at: Updated information and services ranging from molecules to humans, including clinical investigations. It is published 12 times a year (monthly) by the American illuminate normal or abnormal regulation and integration of physiological mech...
متن کاملPersistent pain model reveals sex difference in morphine potency.
Central or systemic administration of agonists directed at the mu or delta opiate receptors generally produce a greater degree of analgesia in males than in females. To date, most studies examining sex-based differences in opioid analgesia have used acute noxious stimuli (i.e., tail-flick and hot plate test); thus the potential dimorphic response of centrally acting opiates in the alleviation o...
متن کاملSex differences in morphine-induced analgesia of visceral pain are supraspinally and peripherally mediated.
Increasing evidence suggests there is a sex difference in opioid analgesia of pain arising from somatic tissue. However, the existence of a sex difference in visceral pain and opioid analgesia is unclear. This was examined in the colorectal distention (CRD) model of visceral pain in the current study. The visceromotor response (vmr) to noxious CRD was recorded in gonadally intact male and femal...
متن کاملSex Differences in -Opioid Receptor Expression in the Rat Midbrain Periaqueductal Gray Are Essential for Eliciting Sex Differences in Morphine Analgesia
Opioid-based narcotics are the most widely prescribed therapeutic agent for the alleviation of persistent pain; however, it is becoming increasingly clear that morphine is significantly less potent in women compared with men. Morphine primarily binds to -opioid receptors (MORs), and the periaqueductal gray (PAG) contains a dense population of MOR-expressing neurons. Via its descending projectio...
متن کاملSex differences in supraspinal morphine analgesia are dependent on genotype.
Several variables have been reported to affect the expression of sex differences in the analgesic potency of morphine. Although the effect of genetic background on morphine analgesia has been well documented, the relevance of genotype to sex differences in morphine analgesia has rarely been considered. The present study investigated morphine dose-response relationships in male and female mice o...
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